Have your bottom, thigh, or leg ever started hurting before, during, or after a genital herpes breakout? Leg pain is more common than you think when living with genital herpes (HSV-2). Other sensations include numbness, tingling, skin sensitivity, overall leg weakness, and shooting pains. For example, when you have skin sensitivity, it can hurt the back of your thighs to sit on a cold toilet. These sensations are much the same as symptoms caused by sciatica and can spread as far as your feet. It's caused by irritated nerves that have become sensitized as the herpes virus travels through your nerve ganglia. When these symptoms persist, it is called Postherpetic Neuralgia and is considered a complication of the Herpes Simplex Virus.